Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and ...

As well as being required for some of the core techniques of molecular biology, reverse transcriptase (RT) enzymes have played a key role in synthetic genetics by enabling synthesis, replication, and ...

Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an ...

Retrons are bacterial genomic elements encoding a reverse transcriptase and a non-coding RNA (ncRNA). Despite their discovery more than three decades ago, the function of retrons remains unknown.